2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 3-{2-[4-(2-Fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenyl-5-propylpyrazole

HRID 1984177Notes

Reaction equation

HRID 1984177 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[CH2:17]([C:20]1[N:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:23]=[C:22]([CH:31]=O)[CH:21]=1)[CH2:18][CH3:19]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][CH2:31][C:22]2[CH:21]=[C:20]([CH2:17][CH2:18][CH3:19])[N:24]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:23]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 862610985-Propyl-1-phenylpyrazole-3-carbaldehyde

Product 1

HCID 160389293-{2-[4-(2-Fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenyl-5-propylpyrazoleYield 59.3%

Procedure

Compound 63 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 5-propyl-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-21d506047ffe4c57ba3ea54d491432c2
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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