2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → HCID 16038995, compound

HRID 1984179Notes

Reaction equation

HRID 1984179 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[C:17]([N:21]1[C:25]([CH:26]=O)=[CH:24][C:23]([CH2:28][CH:29]([CH3:31])[CH3:30])=[N:22]1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([N:21]1[C:25]([CH2:26][NH:16][CH2:15][CH2:14][N:11]2[CH2:10][CH2:9][N:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[CH2:13][CH2:12]2)=[CH:24][C:23]([CH2:28][CH:29]([CH3:31])[CH3:30])=[N:22]1)([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 866110582-t-Butyl-5-iso-butylpyrazole-3-carbaldehyde

Product 1

HCID 16038995HCID 16038995, compoundYield 60.2%

Procedure

Compound 65 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 2-t-butyl-5-iso-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-7a204f595e0e4460b4d809869635851d
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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