2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 5-Iso-butyl-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazole

HRID 1984180Notes

Reaction equation

HRID 1984180 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[CH2:17]([C:21]1[N:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:24]=[C:23]([CH:32]=O)[CH:22]=1)[CH:18]([CH3:20])[CH3:19]>>[CH2:17]([C:21]1[N:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:24]=[C:23]([CH2:32][NH:16][CH2:15][CH2:14][N:11]2[CH2:10][CH2:9][N:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[CH2:13][CH2:12]2)[CH:22]=1)[CH:18]([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 592816115-Isobutyl-1-phenyl-1H-pyrazole-3-carbaldehyde

Product 1

HCID 160389965-Iso-butyl-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazoleYield 71.8%

Procedure

Compound 66 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 5-iso-butyl-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-305a80ded2344579a23b7c629f58474d
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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