2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 3-{2-[4-(2-Fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-5-(furan-2-yl)-1-phenylpyrazole

HRID 1984181Notes

Reaction equation

HRID 1984181 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[C:17]1([N:23]2[C:27]([C:28]3[O:29][CH:30]=[CH:31][CH:32]=3)=[CH:26][C:25]([CH:33]=O)=[N:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][CH2:33][C:25]2[CH:26]=[C:27]([C:28]3[O:29][CH:30]=[CH:31][CH:32]=3)[N:23]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:24]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 592816101-Phenyl-5-(2-furyl)pyrazole-3-carbaldehyde

Product 1

HCID 160389263-{2-[4-(2-Fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-5-(furan-2-yl)-1-phenylpyrazoleYield 86.3%

Procedure

Compound 67 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 1-phenyl-5-(2-furyl)pyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-f81ba190646f445a896aa9f4070583b8
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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