3-methyl-1H-pyrazole-5-carbaldehyde → 3-{2-[4-(3-Chlorophenyl)piperazin-1-yl]ethyl}aminomethyl-5-methylpyrazole

HRID 1984186Notes

Reaction equation

HRID 1984186 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:17][C:18]1[NH:22][N:21]=[C:20]([CH:23]=O)[CH:19]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][CH2:23][C:20]3[CH:19]=[C:18]([CH3:17])[NH:22][N:21]=3)[CH2:12][CH2:13]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 45602443-methyl-1H-pyrazole-5-carbaldehydeHCID 127267362-(4-(3-Chlorophenyl)piperazin-1-yl)ethan-1-amine

Product 1

HCID 160389993-{2-[4-(3-Chlorophenyl)piperazin-1-yl]ethyl}aminomethyl-5-methylpyrazoleYield 60.4%

Procedure

Compound 73 was prepared using the same method as that of Example 1 except that 4-(3-chlorophenyl)piperazin-1-ylethylamine and 5-methylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-73f2c7f3c2a747adacd0f27eca8637ae
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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