2-(4-(3-Chlorophenyl)piperazin-1-yl)ethan-1-amine → 1-t-Butyl-5-iso-butyl-3-{2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl}aminomethylpyrazole
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[C:17]([N:21]1[C:25]([CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:24][C:23]([CH:30]=O)=[N:22]1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([N:21]1[C:25]([CH2:26][CH:27]([CH3:28])[CH3:29])=[CH:24][C:23]([CH2:30][NH:16][CH2:15][CH2:14][N:11]2[CH2:10][CH2:9][N:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[CH2:13][CH2:12]2)=[N:22]1)([CH3:20])([CH3:19])[CH3:18]Participants
3
Procedure
Compound 77 was prepared using the same method as that of Example 1 except that 4-(3-chlorophenyl)piperazin-1-ylethylamine and 1-t-butyl-5-iso-butylpyrazole-3-carbaldehyde were used.
Sources & evidence
- ORD record
- ord-374e4c2d60e243da86eddda99d799e5f
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07544686B2
Reaction notes
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