4-(4-Chlorobenzhydryl)piperazin-1-ylethylamine → 1-t-Butyl-3-{2-[4-(4-chlorobenzhydryl)piperazin-1-yl]ethyl}aminomethyl-5-propylpyrazole

HRID 1984194Notes

Reaction equation

HRID 1984194 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH:6]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][NH2:21])[CH2:15][CH2:14]2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH2:24]([C:27]1[N:31]([C:32]([CH3:35])([CH3:34])[CH3:33])[N:30]=[C:29]([CH:36]=O)[CH:28]=1)[CH2:25][CH3:26]>>[C:32]([N:31]1[C:27]([CH2:24][CH2:25][CH3:26])=[CH:28][C:29]([CH2:36][NH:21][CH2:20][CH2:19][N:16]2[CH2:15][CH2:14][N:13]([CH:6]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:23][CH:22]=3)[CH2:18][CH2:17]2)=[N:30]1)([CH3:35])([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 142106204-(4-Chlorobenzhydryl)piperazin-1-ylethylamineHCID 862610955-Propyl-1-t-butylpyrazole-3-carbaldehyde

Product 1

HCID 689730121-t-Butyl-3-{2-[4-(4-chlorobenzhydryl)piperazin-1-yl]ethyl}aminomethyl-5-propylpyrazoleYield 86%

Procedure

Compound 93 was prepared using the same method as that of Example 1 except that 4-(4-chlorobenzhydryl)piperazin-1-ylethylamine and 5-propyl-1-t-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-3c50a81e880f4db688b0b7089d743a0c
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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