4-(4-Chlorobenzhydryl)piperazin-1-ylethylamine → 5-Iso-butyl-3-{2-[4-(4-chlorobenzhydryl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazole

HRID 1984197Notes

Reaction equation

HRID 1984197 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH:6]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][NH2:21])[CH2:15][CH2:14]2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH2:24]([C:28]1[N:32]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:31]=[C:30]([CH:39]=O)[CH:29]=1)[CH:25]([CH3:27])[CH3:26]>>[CH2:24]([C:28]1[N:32]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:31]=[C:30]([CH2:39][NH:21][CH2:20][CH2:19][N:16]2[CH2:15][CH2:14][N:13]([CH:6]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:23][CH:22]=3)[CH2:18][CH2:17]2)[CH:29]=1)[CH:25]([CH3:27])[CH3:26]

Participants

3

Reactant 2

HCID 142106204-(4-Chlorobenzhydryl)piperazin-1-ylethylamineHCID 592816115-Isobutyl-1-phenyl-1H-pyrazole-3-carbaldehyde

Product 1

HCID 689729975-Iso-butyl-3-{2-[4-(4-chlorobenzhydryl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazoleYield 95%

Procedure

Compound 96 was prepared using the same method as that of Example 1 except that 4-(4-chlorobenzhydryl)piperazin-1-ylethylamine and 5-iso-butyl-1-phenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-c90bf313eaa64af6a119a1bb880eb03a
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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