4-(4-Chlorobenzhydryl)piperazin-1-ylethylamine → 3-{2-[4-(4-Chlorobenzhydryl)piperazin-1-yl]ethyl}aminomethyl-5-(4-cyclohexylphenyl)-1-phenylpyrazole

HRID 1984202Notes

Reaction equation

HRID 1984202 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH:6]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][NH2:21])[CH2:15][CH2:14]2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH:24]1([C:30]2[CH:35]=[CH:34][C:33]([C:36]3[N:40]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)[N:39]=[C:38]([CH:47]=O)[CH:37]=3)=[CH:32][CH:31]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([N:13]2[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][NH:21][CH2:47][C:38]3[CH:37]=[C:36]([C:33]4[CH:34]=[CH:35][C:30]([CH:24]5[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]5)=[CH:31][CH:32]=4)[N:40]([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)[N:39]=3)[CH2:17][CH2:18]2)[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 142106204-(4-Chlorobenzhydryl)piperazin-1-ylethylamineHCID 862611315-(4-Cyclohexylphenyl)-1-phenylpyrazole-3-carbaldehyde

Product 1

HCID 160390823-{2-[4-(4-Chlorobenzhydryl)piperazin-1-yl]ethyl}aminomethyl-5-(4-cyclohexylphenyl)-1-phenylpyrazoleYield 31%

Procedure

Compound 101 was prepared using the same method as that of Example 1 except that 4-(4-chlorobenzhydryl)piperazin-1-ylethylamine and 5-(4-cyclohexyl phenyl)-1-phenyl pyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-8f33759279b6490c8720ede49064795c
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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