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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1984204Generated: October 25, 2026

Ethyl formate → Rac-5-isopropyl-2-oxo-cyclohexanecarbaldehyde

https://huagongshe.com/reaction/1984204

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl formateHCID 8025—
Reactant4-IsopropylcyclohexanoneHCID 79488—
ReactantSodium MethoxideHCID 10942334—
SolventDiethyl EtherHCID 3283—
ProductRac-5-isopropyl-2-oxo-cyclohexanecarbaldehydeHCID 54180615—

Reaction Steps

A solution of ethyl formate (6 mmol) in diethyl ether (2 ml) was added dropwise to a suspension of sodium methoxide (6 mmol) and 4-isopropyl-cyclohexanone (3 mmol) in absolute diethyl ether (3 ml) and after complete evolution of the gas the reaction mixture was stirred overnight at room temperature. The solid formed was filtered off, washed with diethyl ether and dried in a high vacuum. The product was obtained as a slightly yellow solid. tR 2.26; MS (pos. Ion.) m/z 169.32 [M+H]+. (J. Org. Chem. 2000, 65(21), 7145-7150).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07544691B2
Source datasetuspto-grants-2009_06
ORD IDord-099bedd1ca284d7eb6695a69f9a6e3f8
Source noteuspto-grants-2009_06