HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl formate → Rac-5-isopropyl-2-oxo-cyclohexanecarbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | 4-Isopropylcyclohexanone | HCID 79488 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Rac-5-isopropyl-2-oxo-cyclohexanecarbaldehyde | HCID 54180615 | — |
Reaction Steps
A solution of ethyl formate (6 mmol) in diethyl ether (2 ml) was added dropwise to a suspension of sodium methoxide (6 mmol) and 4-isopropyl-cyclohexanone (3 mmol) in absolute diethyl ether (3 ml) and after complete evolution of the gas the reaction mixture was stirred overnight at room temperature. The solid formed was filtered off, washed with diethyl ether and dried in a high vacuum. The product was obtained as a slightly yellow solid. tR 2.26; MS (pos. Ion.) m/z 169.32 [M+H]+. (J. Org. Chem. 2000, 65(21), 7145-7150).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-099bedd1ca284d7eb6695a69f9a6e3f8 |
| Source note | uspto-grants-2009_06 |