HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1984216Generated: November 3, 2026
2,6-Dichloropurine → [2-(3-Chloro-propoxy)-phenyl]-(2-chloro-9H-purin-6-yl)-amine
https://huagongshe.com/reaction/1984216
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,6-Dichloropurine | HCID 5324412 | — |
| Reactant | 2-(3-Chloropropoxy)aniline | HCID 10012643 | — |
| Solvent | 1-Pentanol | HCID 6276 | — |
| Product | [2-(3-Chloro-propoxy)-phenyl]-(2-chloro-9H-purin-6-yl)-amine | HCID 178478467 | — |
Reaction Steps
2,6-Dichloropurine (10 mmol) and 2-(3-Chloro-propoxy)-phenylamine (˜20 mmol) are dissolved in 1-pentanol and heated up to 70° C. and the mixture is stirred at this temperature for 5 hours. While cooling down to R the product precipitated. The solid material was filtered off and washed with 1-pentanol and diethyl ether. A solid powder with mp. 205° C., Rf=0.42 (CH2Cl2/MeOH=10:1) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07544688B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-44a3daa95e4b454cbc74ce2eaa51c4c9 |
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| Source note | uspto-grants-2009_06 |
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