HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 4-Cyclopentylamino-6-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinazoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride | HCID 11183940 | — |
| Reactant | 4-Cyclopentylamino-6-hydroxy-quinazoline-2-carbonitrile | HCID 68647660 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Cyclopentylamino-6-[2-(4-methyl-piperazin-1-yl)-ethoxy]-quinazoline-2-carbonitrile | HCID 68647385 | — |
Reaction Steps
4-Cyclopentylamino-6-hydroxy-quinazoline-2-carbonitrile (0.4 mmol), 1-(2-Chloro-ethyl)-4-methyl-piperazine dihydrochloride (0.55 mmol) and cesium carbonate (4 mmol) are stirred in DMF (5 ml) at RT for 20 hours. The suspension is filtered, washed with little DMF and water is added to the filtrate until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 110-112° C., Rf=0.48 (CH2Cl2/MeOH=9:2) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544688B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-118402fb13884095b3ce6c89cdf9146a |
| Source note | uspto-grants-2009_06 |