HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(2,2-Dimethyl-propylamino)-6-(pyridin-3-ylmethoxy)-quinazoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-(Chloromethyl)pyridine hydrochloride | HCID 23394 | — |
| Reactant | 4-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile | HCID 68647238 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2,2-Dimethyl-propylamino)-6-(pyridin-3-ylmethoxy)-quinazoline-2-carbonitrile | HCID 68647453 | — |
Reaction Steps
4-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile (0.25 mmol), 3-chloromethyl-pyridine hydrochloride (0.38 mmol) and cesium carbonate (2.5 mmol) are stirred in DMF (3 ml) at RT for 20 hours. Water is added until a clear solution is formed. Then more water is added until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 156-158° C., Rf=0.35 (CH2Cl2/MeOH=15:1) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544688B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-1dd0f91978d045258b36a5cbf3321be8 |
| Source note | uspto-grants-2009_06 |