HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 68647533, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | 4-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile | HCID 68647238 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68647533 | HCID 68647533 | — |
Reaction Steps
4-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile (0.23 mmol), 2-chloromethyl-pyridine hydrochloride (0.35 mmol) and cesium carbonate (2.3 mmol) are stirred in DMF (3 ml) at RT for 20 hours. Water is added until a clear solution is formed. Then more water is added until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 160° C., R=0.4 (CH2Cl2/MeOH=15:1) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544688B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-c827fe0f20fa48139cf7c047afeffad4 |
| Source note | uspto-grants-2009_06 |