Hydrochloric Acid → HCID 69001664, compound

Participants

Reaction Steps

To a solution of (S,S)-5-(1H-indole-2-carbonyl)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (124 mg, 0.36 mmol) in formic acid was added 5.0 N HCl (75 μL, 1.82 mmol). After 1 h at rt, the solution was diluted with MeOH (30 mL) and concentrated to give a purple solid (87 mg, 99%). MS (ESI): mass calcd. for C14H15N3O, 241.12; m/z found, 242.3 [M+H]+. 1H NMR (MeOD): 7.67-7.63 (m, 1H), 7.49-7.44 (m, 1H), 7.28-7.22 (m, 1H), 7.12-7.05 (m, 1H), 7.01-6.97 (m, 1H), 5.49 (s, 1H), 5.41-5.02 (m, 1H), 4.58 (s, 1H), 4.28-3.39 (m, 4H), 3.33-3.29 (m, 1H), 2.32-2.21 (m, 1H), 2.13-2.04 (m, 1H).

Provenance & Evidence