Trifluoroacetic acid → HCID 69056946, compound

Participants

Reaction Steps

A solution of [1-(1H-indole-2-carbonyl)-pyrrolidin-3-yl]-methyl-carbamic acid tert-butyl ester (0.500 g, 1.46 mmol) in CH2Cl2 (20 mL) was treated with TFA (8 mL). After 18 h at rt, the mixture was concentrated to give the title compound (520 mg, 99%). MS (ESI): mass calcd. for C16H17N3O, 243.14; m/z found, 244.4 [M+H]+. MS (ESI): mass calcd. for C14H16N3O, 243.43; m/z found, 244.3 [M+H]+. 1H NMR (MeOD): 7.68-7.63 (m, 1H), 7.48-7.43 (m, 1H), 7.28-7.21 (m, 1H), 7.11-7.05 (m, 1H), 7.05-7.00 (m, 1H), 4.44-3.76 (m, 5H), 2.85-2.74 (m, 3H), 2.67-2.08 (m, 2H).

Provenance & Evidence