HCID 10214932, compound → HCID 10171655, compound

HRID 1984306Notes

Reaction equation

HRID 1984306 reaction equation
[CH:1]1([C:4]2[N:9]=[C:8]([N:10]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]3)[C:7]([CH3:17])=[C:6]([N:18]3[CH2:21][CH:20](C)[CH2:19]3)[N:5]=2)[CH2:3][CH2:2]1.N1(C2N=C(C3CC3)N=C(N3CC(O)C3)C=2C)CCCCCC1.C1(C2N=C(N3CCCCCC3)C=C(N3CC(C)C3)N=2)CC1.N1(C2N=C(C3CC3)N=C(N3CCCCCC3)C=2)CCC1.C1(C2N=C(N3CCCCCC3)C(C)=C(N3CC(F)C3)N=2)CC1>>[N:18]1([C:6]2[N:5]=[C:4]([CH:1]3[CH2:2][CH2:3]3)[N:9]=[C:8]([N:10]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]3)[C:7]=2[CH3:17])[CH2:21][CH2:20][CH2:19]1

Participants

6

Reactant 5

HCID 10214932HCID 10214932, compoundHCID 44430462HCID 44430462, compoundHCID 44430467HCID 44430467, compoundHCID 44430472HCID 44430472, compoundHCID 44430473HCID 44430473, compound

Product 1

HCID 10171655HCID 10171655, compound

Procedure

1-[2-cyclopropyl-5-methyl-6-(3-methylazetidin-1-yl)pyrimidin-4-yl]azepane; 1-(6-azepan-1-yl-2-cyclopropyl-5-methylpyrimidin-4-yl)azetidin-3-ol; 1-[2-cyclopropyl-6-(3-methylazetidin-1-yl)pyrimidin-4-yl)azepane; 1-(6-azetidin-1-yl-2-cyclopropylpyrimidin-4-yl)azepane and 1-[2-cyclopropyl-6-(3-fluoroazetidin-1-yl)-5-methylpyrimidin-4-yl]azepane, or pharmaceutically acceptable salts thereof.

Sources & evidence

ORD record
ord-c58c39ce07b1420ca519c26c957ac4bd
Source dataset
uspto-grants-2009_06
Patent number
US07544675B2

Reaction notes

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