HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fumaric Acid → HCID 69035726, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | HCID 44430474 | HCID 44430474 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | HCID 69035726 | HCID 69035726 | 58% |
Reaction Steps
A solution of fumaric acid (0.6 g) in isopropanol (4 ml) is added to a solution of 1-[2-cyclopropyl-6-(3-fluoro-azetidin-1-yl)-pyrimidin-4-yl]azepane in diisopropyl ether (10 ml). The mixture is triturated, then filtered, recrystallized from diisopropyl ether and dried in vacuo to afford pure 1-[2-cyclopropyl-6-(3-fluoro-azetidin-1-yl)-pyrimidin-4-yl]azepane fumarate (3:2) 195 (1.2 g, 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544675B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-f4ecc405ba874571adb43afa33e398e6 |
| Source note | uspto-grants-2009_06 |