Ammonia → HCID 66958969, compound

HRID 1984523Notes

Reaction equation

HRID 1984523 reaction equation
[CH3:1][C:2]([S:18]([CH3:21])(=[O:20])=[O:19])([CH3:17])[CH2:3][C:4]1[N:8]([CH2:9][CH2:10][CH3:11])[N:7]=[C:6]([C:12](OCC)=[O:13])[CH:5]=1.[NH3:22]>CO>[CH3:1][C:2]([S:18]([CH3:21])(=[O:20])=[O:19])([CH3:17])[CH2:3][C:4]1[N:8]([CH2:9][CH2:10][CH3:11])[N:7]=[C:6]([C:12]([NH2:22])=[O:13])[CH:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66958747HCID 66958747, compound

Product 1

HCID 66958969HCID 66958969, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
150 °C

Procedure

A pressure vessel containing ethyl 5-[2-methyl-2-(methylsulfonyl)propyl]-1-propyl-1H-pyrazole-3-carboxylate (9.4 g, 29.7 mmol) and ammonia (50 mL of a 7 N solution in methanol), and the vessel was sealed and heated at 150° C. for 41 hours and allowed to cool to room temperature. The volatiles were removed under reduced pressure to provide 8.5 g of 5-[2-methyl-2-(methylsulfonyl)propyl]-1-propyl-1H-pyrazole-3-carboxamide as a brown oil.

Workup

  1. customwas sealed
  2. temperatureto cool to room temperature
  3. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-c2dd4cb26e2e423c98c4b8f4af17a70e
Source dataset
uspto-grants-2009_06
Patent number
US07544697B2

Reaction notes

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