HCID 90889006, compound → HCID 68998531, compound

Participants

Reaction Steps

A solution of the ketal 198a (6.0 g, 13.7 mmol) in acetone (60 ml), HCl aq. 1N (30 ml) and conc. aq. formaldehyde (8 ml) was heated to 48° C. for 15 h. The mixture was concentrated to a total weight of 46 g, whereupon an orange oil separated out, and CH2Cl2 was added (200 ml). The orange oil went in the organic phase, while water (27 ml) separated out and was removed. The CH2Cl2 layer was rinsed with a small amount of water (20 ml), dried (MgSO4), and concentrated to afforded the crude ketone as hemiaminal (5.1 g, 88%).

Provenance & Evidence