2,4-Dichloro-5-methylbenzene-1-sulphonyl chloride → HCID 57718252, compound

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Reaction Steps

2,4-Dichloro-5-methyl-N-{4-methyl-5-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-pyridin-2-yl}-benzenesulfonamide was prepared from 2-amino-5-bromo-4-methylpyridine and 4-(N-piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichloro-5-methylphenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 13.20 (1H, br s, NH), 8.40 (1H, s, A-ring CH ortho to 2×Cl), 8.03 (1H, s, A-ring CH ortho to SO2NH), 7.53 & 7.04 (2×2H, 2×d, 2×J 10 Hz, Ar CH's of C-ring), 7.41 & 7.15 (2×1H, 2×s, pyridyl CH's), 2.91-2.83 (4H, m, CH2NCH2), 2.38 & 2.23 (2×3H, 2×s, 2×CH3), 1.61-1.48 (4H, m, CH2CH2CH2CH2CH2), 1.39-1.28 (2H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.73 minutes. LC/MS rt=7.43 minutes, 586/588 (MH+).

Provenance & Evidence