Benzenesulfonyl chloride, 2,4-dichloro- → 2,4-Dichloro-N-{6-ethyl-5-[4-(morpholine-4-sulfonyl)-phenylsulfanyl]-pyridin-2-yl}-benzenesulfonamide

Participants

Reaction Steps

Prepared from 2-amino-5-bromo-6-ethylpyridine and 4-(N-morpholinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichlorophenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.00 (1H, d, J 10 Hz, A-ring CH ortho to SO2NH), 7.50 & 6.98 (2×2 H, 2×d, C-ring CH's), 7.45 (1H, d, J 10 Hz, A-ring CH ortho to Cl), 7.35 (1H, s, A ring CH ortho to 2×Cl), 7.26 & 6.74 (2×1H, 2×d, 2×J 10 Hz, pyridyl CH's), 3.63-3.56 (4H, m, CH2OCH2), 2.88-2.79 (4H, m, CH2NCH2), 2.72 (3H, q, J 8 Hz, CH2CH3), 1.09 (3H, t, J 8 Hz, CH2CH3). Hplc (Luna 2, Gradient 5): rt=6.19 minutes. LC/MS rt=6.86 minutes, 588/590 (MH+).

Provenance & Evidence