HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride → 2-Chloro-N-{6-ethyl-5-[4-(morpholine-4-sulfonyl)-phenylsulfanyl]-pyridin-2-yl}-4-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride | HCID 2736675 | — |
| Reactant | 5-Bromo-6-ethylpyridin-2-amine | HCID 21710338 | — |
| Reactant | 4-(N-morpholinylsulfonyl)thiophenol | HCID 57718313 | — |
| Product | 2-Chloro-N-{6-ethyl-5-[4-(morpholine-4-sulfonyl)-phenylsulfanyl]-pyridin-2-yl}-4-trifluoromethyl-benzenesulfonamide | HCID 57718194 | — |
Reaction Steps
Prepared from 2-amino-5-bromo-6-ethylpyridine and 4-(N-morpholinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2-chloro-4-trifluoromethylphenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.41 (1H, d, J 10 Hz, A-ring CH ortho to SO2NH), 7.81-7.63 (5H, m, Ar CH's), 7.20 (2H, d, 2×C-ring CH's), 6.94 (1H, d, J 10 Hz, pyridyl CH's), 3.83-3.77 (4H, m, CH2OCH2), 3.09-2.98 (4H, m, CH2NCH2), 2.93 (3H, q, J 9 Hz, CH2CH3), 1.31 (3H, t, J 9 Hz, CH2CH3). Hplc (Luna 2, Gradient 5): rt=6.26 minutes. LC/MS rt=6.92 minutes, 622 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544702B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-2674fe47ddb348b5afd4f03c805c09b3 |
| Source note | uspto-grants-2009_06 |