HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride → 2-Chloro-N-{5-[4-(morpholine-4-sulfonyl)-phenylsulfanyl]-6-trifluoromethyl-pyridin-2-yl}-4-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride | HCID 2736675 | — |
| Reactant | 5-Bromo-6-(trifluoromethyl)pyridin-2-amine | HCID 45789790 | — |
| Reactant | 4-(N-morpholinylsulfonyl)thiophenol | HCID 57718313 | — |
| Product | 2-Chloro-N-{5-[4-(morpholine-4-sulfonyl)-phenylsulfanyl]-6-trifluoromethyl-pyridin-2-yl}-4-trifluoromethyl-benzenesulfonamide | HCID 57718236 | — |
Reaction Steps
Prepared from 2-amino-5-bromo-6-trifluoromethylpyridine and 4-(N-morpholinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2-chloro-4-trifluoromethylphenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.31 (1H, d, J 10 Hz, A-ring CH ortho to SO2NH), 7.45 (1H, s, A ring CH ortho to CF3 & Cl), 7.65-7.50 & 7.26-7.15 (4H & 3H, 2×m, Ar CH's), 3.71-3.61 (4H, m, CH2OCH2), 2.95-2.86 (4H, m, CH2NCH2). Hplc (Luna 2, Gradient 5): rt=6.53 minutes. LC/MS rt=7.06 minutes, 662 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544702B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-866c7a508e0c459c89ec0b7058708fff |
| Source note | uspto-grants-2009_06 |