Benzenesulfonyl chloride, 2,4-dichloro- → HCID 57718199, compound

HRID 1984602Notes

Reaction equation

[CH2:1]([C:5]1[N:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:6]=1[S:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)(=[O:21])=[O:20])=[CH:15][CH:14]=1)[CH2:2][CH2:3][CH3:4].[Cl:28][C:29]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:30]=1[S:36](Cl)(=[O:38])=[O:37]>>[CH2:1]([C:5]1[N:10]=[C:9]([NH:11][S:36]([C:30]2[CH:31]=[CH:32][C:33]([Cl:35])=[CH:34][C:29]=2[Cl:28])(=[O:38])=[O:37])[CH:8]=[CH:7][C:6]=1[S:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)(=[O:20])=[O:21])=[CH:15][CH:14]=1)[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 204419Benzenesulfonyl chloride, 2,4-dichloro-

HCID 57718188HCID 57718188, compound

Product 1

HCID 57718199HCID 57718199, compound

Procedure

Prepared from 6-butyl-5-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-pyridin-2-ylamine and 2,4-dichlorobenzenesufonyl chloride using General Method 11 step 2 to give N-{6-butyl-5-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-pyridin-2-yl}-2,4-dichloro -benzenesulfonamide. 1HNMR CDCl3 8.10 (1H, d), 7.58 (2H, d), 7.47 (1H, s), 7.36 (1H, d), 7.07 (2H, d), 6.81 (1H, d), 2.97 (4H, m), 2.80 (2H, t), 1.15-1.65 (10H, m), 0.81 (3H, t). LCMS (Luna 2, ): rt=8.11 minutes, 612 (M−H)−.

Sources & evidence

ORD record: ord-db6655bb06f048c1a516a78f3c9c4728
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544702B2

Reaction notes

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