HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-Isobutyl-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-oxobutanoate | HCID 82395 | — |
| Reactant | 2-Amino-4-methylpentanamide hydrochloride | HCID 12866300 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Isobutyl-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione | HCID 19770792 | 74.7% |
Reaction Steps
To a solution of DL-leucinamide hydrochloride (1.5 g, 9 mmol) in water (40 ml), adjusted to pH 9.5 with 10% sodium hydroxide, ethyl-4-oxobutanoate (1g, 7.5 mmol) was added. The mixture was placed in a microwave oven and refluxed for 1 hour. Water was then evaporated under vacuum and the residue was chromatographated over silica gel (CH2Cl2/MeOH/NH4OH 98/2/0.1) to afford 1.1 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544705B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-e3a3d6cec79b435bb9f71291109b7566 |
| Source note | uspto-grants-2009_06 |