4-Amino-2-(ethylthio)-5-(hydroxymethyl)pyrimidine → 4-Amino-2-(ethylthio)pyrimidine-5-carbaldehyde

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Reaction Steps

To a solution of 4-amino-5-hydroxymethyl-2-(ethylthio)pyrimidine (6-1) (9.6 g, 51.89 mmol) in CHCl3 (1 L) was added MnO2 (86.9 g, 415 mmol, 8 equiv). The suspension was stirred at rt overnight. The mixture was filtered through celite and washed with CHCl3. The combined filtrate was concentrated to give the titled compound (6-2). LRMS m/z (M+H) Calcd. 184.1, found 184.1.

Provenance & Evidence