HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminotetrahydropyran → HCID 24783670, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | 3-[2-(5-Methyl-3-phenyl-4-isoxazolyl)ethynyl]benzoic acid | HCID 68852800 | — |
| Product | HCID 24783670 | HCID 24783670 | 87% |
Reaction Steps
As described for example 7b, 3-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-benzoic acid (250 mg; 0.82 mmol) was converted (using 4-amino-tetrahydropyrane instead of aminomethylcyclopropane) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 276 mg, 87%) which was obtained as a white solid. MS: m/e=387.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544704B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-6a5d700d0b324d14a9e1be4fa2101860 |
| Source note | uspto-grants-2009_06 |