HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodo-6-methylpyridazine → 3-Methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodo-6-methylpyridazine | HCID 12680258 | — |
| Reactant | 4-Ethynyl-5-methyl-3-phenyl-isoxazole | HCID 53434647 | — |
| Product | 3-Methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridazine | HCID 24783673 | 80% |
Reaction Steps
As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (70 mg, 0.38 mmol) was converted (using 3-iodo-6-methyl-pyridazine instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 84 mg, 80%) which was obtained as a light brown solid. MS: m/e=276.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544704B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-c8c0af1a85014e8db4270e492f274968 |
| Source note | uspto-grants-2009_06 |