HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2-iodopyridine → 3-Chloro-2-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2-iodopyridine | HCID 10847607 | — |
| Reactant | 4-Ethynyl-5-methyl-3-phenyl-isoxazole | HCID 53434647 | — |
| Product | 3-Chloro-2-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridine | HCID 68852347 | 78% |
Reaction Steps
As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (64 mg, 0.35 mmol) was converted [using 3-chloro-2-iodopyridine (prepared according to Eur. J. Org. Chem. (24), 4181, 2002) instead of 2-chloro-4-iodopyridine] to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 81 mg, 78%) which was obtained as a light yellow solid. MS: m/e=295.2/297.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544704B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-f4516dd95e814bdd9231e5afcf5bb563 |
| Source note | uspto-grants-2009_06 |