4-Ethynyl-5-methyl-3-phenyl-isoxazole → 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-thiazole-4-carboxylic acid ethyl ester

Participants

Reaction Steps

As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (51 mg, 0.28 mmol) was converted (using 5-iodo-2-methyl-thiazole-4-carboxylic acid ethyl ester instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 83 mg, 84%) which was obtained as a light brown solid. MS: m/e=353.2 [M+H]+.

Provenance & Evidence