4-Aminotetrahydropyran → HCID 24783155, compound

Participants

Reaction Steps

As described for example 7b, 2-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-isonicotinic acid (50 mg; 0.16 mmol) instead of 3-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-benzoic acid was converted (using 4-amino-tetrahydropyrane instead of aminomethylcyclopropane) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 46 mg, 73%) which was obtained as a yellow solid. MS: m/e=388.2 [M+H]+.

Provenance & Evidence