HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-iodopyridine → 2-Chloro-6-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-iodopyridine | HCID 18931860 | — |
| Reactant | 4-Ethynyl-5-methyl-3-phenyl-isoxazole | HCID 53434647 | — |
| Product | 2-Chloro-6-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridine | HCID 24783412 | 87% |
Reaction Steps
As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (92 mg, 0.50 mmol) was converted (using 2-chloro-6-iodopyridine instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 129 mg, 87%) which was obtained as a light yellow oil. MS: m/e=295.1/297.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544704B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-8717929288bc4bd28642ef21c61f5b5d |
| Source note | uspto-grants-2009_06 |