4-Ethynyl-5-methyl-3-phenyl-isoxazole → HCID 24784179, compound

Participants

Reaction Steps

As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (92 mg, 0.50 mmol) was converted [using 2-iodo-5-methyl-1-phenyl-1H-imidazole (prepared from 5-methyl-1-phenyl-1H-imidazole by reaction of 4(5)-methyl-1-phenyl-1H-imidazole with N-iodosuccinimide in N,N-dimethylformamide at ambient temperature) instead of 2-chloro-4-iodopyridine] to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 35 mg, 21%) which was obtained as a brown solid. MS: m/e=340.2 [M+H]+.

Provenance & Evidence