Acetic Acid → HCID 68852660, compound

Participants

Reaction Steps

To a solution of 3-methyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine (Eur. J. Med. Chem. 10(5), 528, 1975; 1.85 g, 13.6 mmol) in acetic acid (50 mL) was added N-iodsuccinimide (4.28 g, 19.0 mmol) and the reaction mixture was stirred for 3 h at ambient temperature. It was concentrated and the residue extracted with aqueous sodium carbonate (sat.) and ethyl acetate. The combined organic layers were dried over sodium sulfate and concentrated. Purification by chromatography (SiO2, dichloromethane:methanol=100:0 to 93:7) afforded the title compound (3.00 g, 84%) as a dark brown solid. MS: m/e=262.0 [M]+.

Provenance & Evidence