HCID 68854758, compound → HCID 86616909, compound

HRID 1984692Notes

Reaction equation

HRID 1984692 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[N:11][C:10]([CH2:14][OH:15])=[N:9]2)=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([CH3:13])=[N:11][C:10]([CH:14]=[O:15])=[N:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 68854758HCID 68854758, compound

Product 1

HCID 86616909HCID 86616909, compoundYield 82.8%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

A suspension of [1-(4-fluoro-phenyl)-5-methyl-1H-[1,2,4]triazol-3-yl]-methanol (2.20 g, 10.6 mmol) and manganese(IV) oxide (10.3 g, 106 mmol) in dichloromethane (110 mL) was heated at reflux for 1 h. After cooling to ambient temperature it was filtered and concentrated affording the title compound (1.80 g, 33%) as a light yellow solid. MS: m/e=206.3 [M+H]+.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1 h
  3. filtrationwas filtered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-0e33d0e7d5b04e0abd1298e2d2570ce6
Source dataset
uspto-grants-2009_06
Patent number
US07544704B2

Reaction notes

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