2-Bromopyridine → HCID 24783669, compound

Participants

Reaction Steps

As described for example 11c, 3-(4-chloro-phenyl)-4-ethynyl-5-methyl-isoxazole (109 mg, 0.50 mmol) instead of 4-ethynyl-5-methyl-3-phenyl-isoxazole was converted (using 2-bromopyridine instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 129 mg, 87%) which was obtained as a light brown solid. MS: m/e=295.1 [M+H]+.

Provenance & Evidence