Hydrochloric Acid → HCID 68944694, compound

Participants

Reaction Steps

A solution cooled at 0° C. of 4.40 g (14.09 mmol) of (3R,4S)-3-[(2S)-2-(tert-butoxycarbonyl)amino-3-methylbutanoyl]-4-methyl-2,5-pyrrolidinedione (preparation: S. G. Davies, D. J. Dixon, J. Chem. Soc., Perkin Trans. 1, 1998, 17, 2635-2643) in 20 ml of dioxane is admixed dropwise with 35 ml of 4N hydrochloric acid solution in 1,4-dioxane. When the addition has been made the mixture is warmed to room temperature and stirred for 2 h, before being concentrated in vacuo. The residue is treated with diethyl ether. The precipitated crystals are filtered off and dried under a high vacuum. Yield: 2.99 g of colorless crystals (86% of theory).

Provenance & Evidence