Triethylamine → HCID 23150913, compound

Participants

Reaction Steps

Triethylamine (6 μL, 0.44 mmol) was added to a solution of 4-chloromethyl-2-dimethylaminopyridine (36 mg, 0.21 mmol) and N-(4-tert-butylphenyl)-2-mercaptobenzamide (36 mg, 0.13 mmol) in N,N-dimethylformamide (1.0 mL) at room temperature, and the mixture was stirred for 68 hours. The mixture was diluted with ethyl acetate (30 mL), the whole was washed with saturated aqueous sodium hydrogen carbonate solution (30 mL) and brine (30 mL) successively, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography to give 19 mg of the target compound as a pale yellow oil. (Yield 22%)

Provenance & Evidence