Thionyl Chloride → HCID 68844582, compound

Participants

Reaction Steps

N-(4-tert-Butylphenyl)-2-(2-hydroxyacetylaminopyridin-4-ylmethylthio)pyridine-3-carboxamide (Compound No. 12-8, 250 mg, 0.55 mmol) was suspended in anhydrous dichloromethane (5.0 mL) under ice-cooling, and thionyl chloride (80 μL, 1.1 mmol) was added thereto. The mixture was stirred for 6 hours at room temperature, and the solvent was evaporated under reduced pressure. The resulting solid was filtered off with ethyl acetate and washed with diethyl ether to give 270 mg of the target compound quantitatively as a pale yellow solid.

Provenance & Evidence