Morpholine → HCID 23151000, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-tert-Butylphenyl)-2-(2-chloroacetylaminopyridin-4-ylmethylthio)pyridine-3-carboxamide (Compound No. 16-1, 50 mg, 0.11 mmol) was suspended in morpholine (1.0 mL), and the mixture was stirred for 2 hours at 80° C. in the sealed tube. Ethyl acetate (50 mL) was added to the reaction mixture, the whole was washed with water (50 mL) and brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, the resulting solid was filtered off with diethyl ether and dried under reduced pressure to give 17 mg of the target compound as a pale yellow solid. (Yield 32%)

Provenance & Evidence