HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(3-trifluoromethoxy-phenyl)-1H-indol-2-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734385 | — |
| Reactant | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Product | (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(3-trifluoromethoxy-phenyl)-1H-indol-2-yl]-methanone | HCID 16739414 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 3-trifluoromethoxybenzene boronic acid. The title compound was obtained in 73% yield as light green foam. MS (m/e): 566.4 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-89edaa65bc104e0c882285743a42b47b |
| Source note | uspto-grants-2010_06 |