Boronic acid, (4-ethylphenyl)- → HCID 68870469, compound

HRID 1984807Notes

Reaction equation

HRID 1984807 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5](OCCCCCCC)=[C:6]([CH:32]=1)[C:7]([NH:9][C@@H:10]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24](OC(F)(F)F)=[CH:23][CH:22]=2)=[CH:17][CH:16]=1)[C:11]([OH:13])=[O:12])=[O:8].[CH2:41]([C:43]1[CH:48]=[CH:47][C:46](B(O)O)=[CH:45][CH:44]=1)[CH3:42]>>[C:18]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]=[CH:20][C:15]([CH2:14][C@H:10]([NH:9][C:7]([C:6]2[CH:32]=[C:2]([C:45]3[CH:46]=[CH:47][CH:48]=[C:43]([CH2:41][CH3:42])[CH:44]=3)[CH:3]=[CH:4][CH:5]=2)=[O:8])[C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 58717891HCID 58717891, compound

Product 1

HCID 68870469HCID 68870469, compoundYield 97.7%

Procedure

3-Biphenyl-4-yl-(2S)-[(3-bromo-benzoyl-amino)-propionic acid (100 mg, 0.23 mmol) was reacted with 4-ethyl phenyl boronic acid (145 mg, 0.69 mmol) by following general procedure D yielding the title compound (101 mg) as a white solid.

Sources & evidence

ORD record
ord-625786e340a84aba908a77e7c3054b35
Source dataset
uspto-grants-2009_06
Patent number
US07544699B2

Reaction notes

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