HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-(2-Amino-5-chloro-benzoylamino)-3-(4'-trifluoromethyl-biphenyl-4-yl)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | 2-(2-Amino-5-chloro-benzoylamino)-3-(4-bromo-phenyl)-propionic acid methyl ester | HCID 68863095 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 2-(2-Amino-5-chloro-benzoylamino)-3-(4'-trifluoromethyl-biphenyl-4-yl)-propionic acid methyl ester | HCID 68869490 | 122.9% |
Reaction Steps
A solution of 2-(2-amino-5-chloro-benzoylamino)-3-(4-bromo-phenyl)-propionic acid methyl ester (0.600 g, 1.45 mmol) in DME (10.0 mL) was reacted with 4-trifluoromethylbenzene boronic acid (0.55 g, 2.91 mmol), Pd(PPh3)4 (0.70 g, 0.14 mmol), and Na2CO3 (2.0N, 3.50 mL, 3.64 mmol) by the general procedure D to give 0.850 g of 2-(2-amino-5-chloro-benzoylamino)-3-(4′-trifluoromethyl-biphenyl-4-yl)-propionic acid methyl ester as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544699B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-2d46f53809f040b9bba184bf5ebf3563 |
| Source note | uspto-grants-2009_06 |