反应详情

870 mg (2.71 mmol) of 6-(4-tert-butylphenoxy)-isoquinoline-3-carboxylic acid (example 295) was reacted with 871 mg (2.71 mmol) of (2S)-amino-3-(4-benzyloxy-phenyl)-propionic acid methyl ester as described in general procedure A. The crude product was purified by flash column chromatography on silica using 3:2 hexane/ethyl acetate as eluent to afford 1.205 g of 3-(4-benzyloxy-phenyl)-2-{[6-(4-tert-butyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-propionic acid methyl-ester as a white solid. LCMS 590 (M+1)+.

1. customThe crude product was purified by flash column chromatography on silica using 3:2 hexane/ethyl acetate as eluent