huagongshe.com
HRID1984828

反应详情

EQUATION

反应方程式

HRID 1984828 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)c1ccc(B(O)O)cc1
HCID2734320

4-tert-Butylphenylboronic acid

C10H15BO2

结构：COC(=O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OC(C)(C)C
HCID21311306

未命名化合物

结构：COC(=O)[C@@H]1Cc2ccc(Oc3ccc(C(C)(C)C)cc3)cc2CN1C(=O)OC(C)(C)C
HCID68869404

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1ccc(Oc2ccc3cc(C(=O)O)ncc3c2)cc1
HCID18457666

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)[O-].CC(=O)[O-].[Cu+2]
催化剂HCID8895

Cupric acetate

C4H6CuO4

PROCEDURE

实验过程

The above phenol (1.20 g, 3.91 mmol) was reacted with 4-(tert-butyl)phenylboronic acid (1.6 eq., 6.26 mmol, 1.11 g ), copper(II) acetate (1.0 eq. 3.91 mmol, 710 mg) as desribed in general procedure G. Flash column chromatography on silica (ethyl acetate/hexanes) provided 750 mg of the desired product, (3S)-7-(4-tert-butylphenoxy)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester.