7-(4-tert-Butylphenoxy)-isoquinoline-3-carboxylic acid → 3-(4-Bromo-phenyl)-(2S)-{[7-(4-tert-butyl-phenoxy)-isoquinoline-3-carbonyl]-amino)-propionic acid methyl ester

Participants

Reaction Steps

500 mg (1.55 mmol) of 7-(4-tert-butylphenoxy)-isoquinoline-3-carboxylic acid (Example 371) was reacted with 441 mg (1.7 mmol) of (2S)-amino-3-(4-bromo-phenyl)-propionic acid methyl ester as described in general procedure A. The crude product was purified by flash column chromatography on silica using 8:2 hexane/ethyl acetate as eluent, to afford 830 mg of the title compound as a white solid.

Provenance & Evidence