HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 57717686, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734660 | — |
| Reactant | HCID 68867921 | HCID 68867921 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57717686 | HCID 57717686 | — |
Reaction Steps
50 mg (0.089 mmol) of 3-(4-bromo-phenyl)-(2S)-{[7-(4-tert-butyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-propionic acid was reacted with 31 mg (0.17 mmol) of 3-chloro-4-fluorophenylboronic acid in toluene as described in procedure D. Column chromatography using 8:2 hexane and ethyl acetate as an eluent gave 46 mg of title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544699B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-4497833e2b52443ebc8e7f320cb1ace1 |
| Source note | uspto-grants-2009_06 |