HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 7-benzyloxy-3,4-dihydro-1H-isoq uinoline-2,3-dicarboxylic acid 2-tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | (3S)-2-((tert-butoxy)carbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | HCID 6712312 | — |
| Product | 7-benzyloxy-3,4-dihydro-1H-isoq uinoline-2,3-dicarboxylic acid 2-tert-butyl ester | HCID 68867857 | 19.2% |
Reaction Steps
2.0 g, (6.8 mmol) of (3S)-7-hydroxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester was reacted with 2.56 g (15.0 mmol) of benzyl bromide as described in general procedure H. The resulting crude product was subjected to hydrolysis as described in general procedure C. The crude product was purified by column chromatography using 1:1 ethyl acetate and hexane as eluent to afford 0.5 g of 7-benzyloxy-3,4-dihydro-1H-isoq uinoline-2,3-dicarboxylic acid 2-tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544699B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-bd40c1a4fd87491fbff5605eff5083c1 |
| Source note | uspto-grants-2009_06 |