HCID 18457633, compound → HCID 11578206, compound

HRID 1984847Notes

Reaction equation

HRID 1984847 reaction equation
[C:1]([C:5]1[CH:30]=[CH:29][C:8]([O:9][C:10]2[CH:19]=[C:18]3[C:13]([CH:14]=[C:15]([C:26](O)=[O:27])[N:16]=[C:17]3[CH2:20][CH:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.C[O:33][C:34](=[O:44])[C@@H:35]([NH2:43])[CH2:36][C:37]1[S:38][C:39]([Br:42])=[CH:40][CH:41]=1>>[Br:42][C:39]1[S:38][C:37]([CH2:36][C@H:35]([NH:43][C:26]([C:15]2[N:16]=[C:17]([CH2:20][CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25]3)[C:18]3[C:13]([CH:14]=2)=[CH:12][CH:11]=[C:10]([O:9][C:8]2[CH:29]=[CH:30][C:5]([C:1]([CH3:3])([CH3:4])[CH3:2])=[CH:6][CH:7]=2)[CH:19]=3)=[O:27])[C:34]([OH:33])=[O:44])=[CH:41][CH:40]=1

Participants

3

Reactant 2

HCID 18457633HCID 18457633, compoundHCID 68771710HCID 68771710, compound

Product 1

HCID 11578206HCID 11578206, compoundYield 87.7%

Procedure

50 mg (0.12 mmol) of 7-(4-tert-butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carboxylic acid (Example 419) was reacted with (2S)-amino-3-(5-bromo-thiophen-2-yl)-propionic acid methyl ester HCl (40.1 mg, 0.14 mmol) as described in general procedure A. The resulting ester was hydrolyzed as described in general procedure C to afford 66.9 mg of the title compound as a white solid.

Sources & evidence

ORD record
ord-2258a5bfe9054a9a82da2ef4adb1c0cc
Source dataset
uspto-grants-2009_06
Patent number
US07544699B2

Reaction notes

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